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FACULTY 교수진

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교수진 소개

엄성희조교수 / Prof. Sung Hee Um shum@skku.edu http://biomed.skku.edu/shum

  • 소속
    생화학 분자생물학 분과
  • 연구실명
    대사질환연구실
  • 전공분야
    인체대사 및 내분비학
  • Location
    6109
  • Phone
    031-299-6123
  • FAX
    031-299-6109

연구소개

비만과 당뇨병 등 대사성 질환들에서 나타나는 공통된 특징은 영양분과 에너지 항상성의 부조절이다. 영양분과 에너지 항상성을 조절하는 신호전달체계에 대한 연구는 대사성 질환에 대한 병리 생리학적 이해를 증진시킬 수 있다. 저희 실험실은 세포가 성장인자와 영양분으로부터 오는 신호를 어떻게 감지하고 연합시켜 여러 대사 작용을 매개하는 지와, 대사질환 같은 병리적 상태에서 이들 신호전달기전의 부조절이 어떻게 일어나는지에 관심을 가지고 연구해오고 있다. 이를 위해 생화학, 분자생물학적 실험과 동물모델, 환자 샘플을 이용하여 영양분과 에너지 항상성의 부조화를 일으키는 신호전달체계의 부조절에 관한 기작을 밝히려고 한다. 이 연구는 대사성 질환 치료를 위한 전략을 개발하고 분자적 표적을 규명하는데 응용될 수 있을 것으로 사료된다.

학력 및 경력

2009-현재

성균관대학교 의과대학 분자세포생물학교실 조교수

2004-2009

Postdoctoral Fellow, University of Cincinnati, College of Medicine, U.S.A

2004

이학박사(생화학), University of Basel, Switzerland

1996-1998

연구원, 목암생명공학연구소

1996

약학석사, 성균관대학교 약학대학 약학과

1994

약학사, 성균관대학교 약학대학 약학과

최근 연구 업적

  1. 2010년 제2기 포스코청암재단 신진교수 생명과학 분야 청암과학펠로쉽 (TJ Park Science Fellowship) 수상
  2. Chau GC,* Im DU,* Kang TM, Bae JM, Won Kim, Pyo SN, Moon EY, and Um SH ** (*equally contribution)(** corresponding author), 2017: mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress. J. Cell Biol, 2016(7), 2091-2105
  3. Lee JW, Lee JY, Um SH*,2 and Moon EY* (*corresponding author), 2017: Synovial cell death is regulated by TNF-α-induced expression of B-cell activating factor through an ERK-dependent increase in hypoxia-inducible factor-1α. Cell Death and Disease, 8(4), e2727
  4. Son SW*, Kim SH*, Moon EY*, Kim DH, Pyo SN, Um SH** (*equally contribution) (**corresponding author), 2016: Prognostic significance and function of the Vacuolar H+- ATPase subunit V1E1 in esophageal squamous cell carcinoma. Oncotarget, 7(31), 49334-49348
  5. Yi SA, Um SH, Lee J, Yoo JH, Bang SY, Park EK, Lee MG, Nam KH, Jeon YJ, Park JW, You JS, Lee SJ, Bae GU, Rhie JW, Kozma SC, Thomas G, Han JW., 2016: S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis. Molecular Cell, 62(3), 443-452
  6. Kim SC, Kim YH, Son SW, Moon EY, Pyo S and Um SH*(* corresponding author), 2015: Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun, in press
  7. Um SH*, Sticker JM, Chau GC, Vintersten K, Mueller M, Gangliff YG, Adams RH, Spetz JF, Elghazi L, Pfluger PT, Pende M, Bernal ME, Tauler A, Tschöp MH, Thomas G and Kozma SC*(* corresponding author), 2015: S6K1-mediated pancreatic b-cell size is independent of intrauterine growth restriction. J Clin Invest, 125(7), 2736-47
  8. Lee KW, Sung CO, Kim JH, Kang M, Yoo HY, Kim HH, Um SH, Kim SH, 2015: CD10 expression is enhanced by Twist1 and associated with poor prognosis in esophageal squamous cell carcinoma with facilitating tumorigenicity in vitro and in vivo. Int J Cancer, 136(2), 310-321
  9. Kim SH, Jang YH, Chau GC, Pyo S and Um SH*, Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma. (*corresponding author) Modern Pathology. 2013 Mar;26(3):327-35.
  10. Kim SH, Chau GC, Jang YH, Lee SI, Pyo S and Um SH*, Clinicopathologic significance and function of mTOR activation in esophageal squamous cell carcinoma, (*corresponding author) Human Pathology. 2013 Feb 44(2):226-36.
  11. Choi K.*, Um SH*, Kwak JH, Park H, Moon E, Kwon S, Pyo S, (*equally contributed), 2012: Suppression of adhension molecule expression by phenanthrene-containing extract of bulbils of Chinese Yam in vascular smooth muscle cells through inhibition of MAPK, Akt and NF-kB. Food and Chemical Toxicology. 2012 May 11. 50(8):2792-804.
  12. Kim KJ, Pyo S, Um SH*. (*corresponding author) S6K2 deficiency enhances ketone body production and increases PPARα activity in the liver. Hepatology. 2012 Jun; 55(6):1727-37, (IF: 11.665)
  13. Lee WJ, Yoon G, Jung YJ, Jeon YS, Hwang YR, Kang KS, Kim YK, Um SH* and Kim SN*.(*corresponding author) Dendrobium moniliforme extract regulates glucose and lipid metabolism through activation of peroxisome proliferator-activated receptor α. Journal of Medicinal Plants Research. 2012 October 25, 6(41): 5452-5459.
  14. Carnevalli L, Masuda K, Frigerio F, Bacquer O, Um SH, Gandin V, Topisirovic I, Sonenberg N, Thomas G, Kozma SC. S6K1 Plays a Critical Role in Early Adipocyte Differentiation. Developmental Cell, 2010, 18(5): 763-774. (IF: 14.202)
  15. Tremblay F, Brule S*, Um SH*, Li Y, Masuda K, Roden M, Sun XJ, Krebs M, Polakiewicz RD, Thomas G, Marette (*equally contributed). Identification of IRS-1 Ser1101 as a novel target of S6K1 in nutrient and obesity-induced insulin resistance Proc Natl Acad Sci, 2007, 104(35):14056-61. (IF: 9.681)
  16. SC. Kozma, Um SH, and G. Thomas Translational Control in Metabolic Diseases: The Role of mTOR Signaling in Obesity and Diabetes Translational Control in Biology and Medicine Cold Spring Harbor Laboratory Press, 2007, Chapter 17, ISBN 0-87969-767-9.
  17. Um SH, D Alessio D, Thomas G Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metabolism. 2006, 3(6):393-402. (IF: 17.770)
  18. Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini P, Kozma SC, Auwerx J and Thomas G Absence of S6K1 Protects Against Age and Diet-Induced Obesity While Enhancing Insulin Sensitivity. Nature, 2004, 431, 200-205. (IF: 36.280)
  19. Gangloff YG, Mueller M, Dann SG, Svoboda P, Sticker M, Spetz JF, Um SH, Brown EJ, Cereghini S, Thomas G, Kozma SC Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development, Mol Cell Biol. 2004, 24(21):9508-16.
  20. Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, Mueller M, Fumagalli S, and Thomas G S6K1 (-/-)/S6K2 (-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.